DNA copy number of a genomic region is the number of copies of the DNA in that region within the genome of the sample. Copy number changes or alterations are a form of genetic variation in the human genome. DNA copy number alterations (CNAs) have been linked to the development and progression of cancer and many diseases.
Array comparative genomic hybridization allows detection and mapping of copy number of DNA segments throughout the genome and it offers a higher resolution level than chromosome-based comparative genomic hybridization. With array CGH, copy number changes at a level of 5-10 kilobases(kb) of DNA sequences can be detected. A number of studies have applied array CGH technology for copy number analysis of hepatocellular carcinoma and have indicated the significance of correlations of frequent genomic aberrations with gene expressions. Therefore, after segmenting the chromosome with array CGH into many pieces with length 5-10 kb…
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